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structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.","bibjson":{"author":[{"initials":"A","lastname":"Achour","name":"Achour A"},{"initials":"K","lastname":"Persson","name":"Persson K"},{"initials":"RA","lastname":"Harris","name":"Harris RA"},{"initials":"J","lastname":"Sundb\ufffd\ufffdck","name":"Sundb\ufffd\ufffdck J"},{"initials":"CL","lastname":"Sentman","name":"Sentman CL"},{"initials":"Y","lastname":"Lindqvist","name":"Lindqvist Y"},{"initials":"G","lastname":"Schneider","name":"Schneider G"},{"initials":"K","lastname":"K\ufffd\ufffdrre","name":"K\ufffd\ufffdrre K"}],"identifier":[{"id":"10.1016/s1074-7613(00)80602-0","type":"doi"},{"id":"9729040","type":"pubmed"}],"issue":["2"],"journal":{"iso_abbreviation":"Immunity","name":""},"pages":["199-208"],"title":"The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.","type":"article","url":"https://www.sciencedirect.com/science/article/abs/pii/S1074761300806020","volume":["9"],"year":[1998]},"in_pmc":"N","in_pmce":"N","open_access":"N"},"resolution":"2.40","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/1bii"},"rcsb":{"url":"https://www.rcsb.org/structure/1bii"}},"species":{"common_name":"Mouse","match_type":"histo:assign_species","scientific_name":"Mus musculus","slug":"mus_musculus"},"tcr":null,"title":"H2-Dd binding \"RGPGRAFVTI\" at 2.40Å resolution","unique_chain_count":3}}