{"display":true,"structure":{"allele":{"alpha":{"identifier":"ipd-imgt:HLA35266","locus":"hla-a","match_type":"histo:exact","name":"HLA-A*02:01","slug":"hla_a_02_01","species_stem":"hla"},"beta":{}},"assemblies":{"1":{"assembly_name":"1c16_1","chains":["A","B"],"downloaded_at":"2022-11-09T14:27:56.847449"},"2":{"assembly_name":"1c16_2","chains":["C","D"],"downloaded_at":"2022-11-09T14:27:57.226277"},"3":{"assembly_name":"1c16_3","chains":["E","F"],"downloaded_at":"2022-11-09T14:27:57.744665"},"4":{"assembly_name":"1c16_4","chains":["G","H"],"downloaded_at":"2022-11-09T14:27:58.091424"}},"assembly_count":null,"assigned_chains":{"beta2m":{"chains":["B","D","F","H"],"match_type":"histo:assign_chains","score":1.0,"sequence":"IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM"},"h2-t22":{"chains":["A","C","E","G"],"match_type":"histo:assign_chains","score":1.0,"sequence":"GSHSLRYFYTAVSRPGLGEPWFIIVGYVDDMQVLRFSSKEETPRMAPWLEQEEADNWEQQTRIVTIQGQLSERNLMTLVHFYNKSMDDSHTLQWLQGCDVEPDRHLCLWYNQLAYDSEDLPTLNENPSSCTVGNSTVPHISQDLKSHCSDLLQKYLEKGKERLLRSDPPKAHVTRHPRPEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQSYTCHVYHEGLPEPLILRWGG"}},"chronology":{"deposition_date":"1999-07-20","deposition_year":1999,"release_date":"2000-01-26","release_year":2000,"revision_date":"2011-07-13","revision_year":2011},"class":"class_i","classical":false,"complex_type":"h2-t22","components":["h2-t22","beta2m"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"hla-a","manually_edited":{},"missing_residues":[],"page_title":"1C16 | Mouse Non-classical MHC Class I molecule H2-T22","pdb_code":"1c16","pdb_title":"Crystal structure analysis of the gamma/delta T cell ligand t22","peptide":{"actual_sequence":null,"epitope_info":{},"features":[],"full_sequence":null,"gap_info":{},"gapped_sequence":null,"length":{"numeric":null,"text":null},"unnatural_amino_acids":[]},"publication":{"abstract":"Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.","bibjson":{"author":[{"initials":"C","lastname":"Wingren","name":"Wingren C"},{"initials":"MP","lastname":"Crowley","name":"Crowley MP"},{"initials":"M","lastname":"Degano","name":"Degano M"},{"initials":"Y","lastname":"Chien","name":"Chien Y"},{"initials":"IA","lastname":"Wilson","name":"Wilson IA"}],"identifier":[{"id":"10.1126/science.287.5451.310","type":"doi"},{"id":"10634787","type":"pubmed"}],"issue":["5451"],"journal":{"iso_abbreviation":"Science","name":""},"pages":["310-4"],"title":"Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold.","type":"article","url":"https://www.science.org/doi/10.1126/science.287.5451.310","volume":["287"],"year":[2000]},"in_pmc":"N","in_pmce":"N","open_access":"N"},"resolution":"3.10","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/1c16"},"rcsb":{"url":"https://www.rcsb.org/structure/1c16"}},"species":{"common_name":"Mouse","match_type":"histo:assign_species","scientific_name":"Mus musculus","slug":"mus_musculus"},"tcr":null,"title":"Mouse Non-classical MHC Class I molecule H2-T22 at 3.10Å resolution","unique_chain_count":2}}