{"display":true,"structure":{"allele":{"alpha":{"identifier":"ipd-imgt:HLA34781","locus":"hla-b","match_type":"histo:exact","name":"HLA-B*42:01","slug":"hla_b_42_01","species_stem":"hla"},"beta":{}},"assemblies":{"1":{"assembly_name":"1hyr_1","chains":["B","A","C"],"downloaded_at":"2022-11-09T14:37:19.720596"}},"assembly_count":null,"assigned_chains":{"mica":{"chains":["C"],"match_type":"histo:assign_chains","score":1.0,"sequence":"MEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPS"},"nkg2d":{"chains":["A","B"],"match_type":"histo:assign_chains","score":1.0,"sequence":"NSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV"}},"chronology":{"deposition_date":"2001-01-21","deposition_year":2001,"release_date":"2001-05-23","release_year":2001,"revision_date":"2011-07-13","revision_year":2011},"class":"class_i","classical":false,"complex_type":"mica_with_nkg2d","components":["nkg2d","mica"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"hla-b","manually_edited":{},"missing_residues":[],"page_title":"1HYR | Non-classical MHC Class I molecule MICA with NKG2D","pdb_code":"1hyr","pdb_title":"Crystal structure of human mica in complex with natural killer cell receptor nkg2d","peptide":{"actual_sequence":null,"epitope_info":{},"features":[],"full_sequence":null,"gap_info":{},"gapped_sequence":null,"length":{"numeric":null,"text":null},"unnatural_amino_acids":[]},"publication":{"abstract":"To date, non-wear detection algorithms commonly employ a 30, 60, or even 90 mins interval or window in which acceleration values need to be below a threshold value. A major drawback of such intervals is that they need to be long enough to prevent false positives (type I errors), while short enough to prevent false negatives (type II errors), which limits detecting both short and longer episodes of non-wear time. In this paper, we propose a novel non-wear detection algorithm that eliminates the need for an interval. Rather than inspecting acceleration within intervals, we explore acceleration right before and right after an episode of non-wear time. We trained a deep convolutional neural network that was able to infer non-wear time by detecting when the accelerometer was removed and when it was placed back on again. We evaluate our algorithm against several baseline and existing non-wear algorithms, and our algorithm achieves a perfect precision, a recall of 0.9962, and an F1 score of 0.9981, outperforming all evaluated algorithms. Although our algorithm was developed using patterns learned from a hip-worn accelerometer, we propose algorithmic steps that can easily be applied to a wrist-worn accelerometer and a retrained classification model.","bibjson":{"author":[{"initials":"P","lastname":"Li","name":"Li P"},{"initials":"DL","lastname":"Morris","name":"Morris DL"},{"initials":"BE","lastname":"Willcox","name":"Willcox BE"},{"initials":"A","lastname":"Steinle","name":"Steinle A"},{"initials":"T","lastname":"Spies","name":"Spies T"},{"initials":"RK","lastname":"Strong","name":"Strong RK"}],"identifier":[{"id":"10.1038/87757","type":"doi"},{"id":"11323699","type":"pubmed"}],"issue":["5"],"journal":{"iso_abbreviation":"Nat. Immunol.","name":""},"pages":["443-51"],"title":"Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.","type":"article","url":"http://www.nature.com/articles/ni0501_443","volume":["2"],"year":[2001]},"in_pmc":"N","in_pmce":"Y","open_access":"Y"},"resolution":"2.70","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/1hyr"},"rcsb":{"url":"https://www.rcsb.org/structure/1hyr"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":null,"title":"Non-classical MHC Class I molecule MICA with NKG2D at 2.70Å resolution","unique_chain_count":2}}