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anti-influenza CD8+ T cell response in HLA-A2-positive adults is almost exclusively directed at residues 58-66 of the virus matrix protein (MP(58-66)). V(beta)17V(alpha)10.2 T cell receptors (TCRs) containing a conserved arginine-serine-serine sequence in complementarity determining region 3 (CDR3) of the V(beta) segment dominate this response. To investigate the molecular basis of immunodominant selection in an outbred population, we have determined the crystal structure of V(beta)17V(alpha)10.2 in complex with MP(58-66)-HLA-A2 at a resolution of 1.4 A. We show that, whereas the TCR typically fits over an exposed side chain of the peptide, in this structure MP(58-66) exposes only main chain atoms. This distinctive orientation of V(beta)17V(alpha)10.2, which is almost orthogonal to the peptide-binding groove of HLA-A2, facilitates insertion of the conserved arginine in V(beta) CDR3 into a notch in the surface of MP(58-66)-HLA-A2. This previously unknown binding mode underlies the immunodominant T cell response.","bibjson":{"author":[{"initials":"GB","lastname":"Stewart-Jones","name":"Stewart-Jones GB"},{"initials":"AJ","lastname":"McMichael","name":"McMichael AJ"},{"initials":"JI","lastname":"Bell","name":"Bell JI"},{"initials":"DI","lastname":"Stuart","name":"Stuart DI"},{"initials":"EY","lastname":"Jones","name":"Jones EY"}],"identifier":[{"id":"10.1038/ni942","type":"doi"},{"id":"12796775","type":"pubmed"}],"issue":["7"],"journal":{"iso_abbreviation":"Nat. Immunol.","name":""},"pages":["657-63"],"title":"A structural basis for immunodominant human T cell receptor recognition.","type":"article","url":"http://www.nature.com/articles/ni942","volume":["4"],"year":[2003]},"in_pmc":"N","in_pmce":"N","open_access":"N"},"resolution":"1.40","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/1oga"},"rcsb":{"url":"https://www.rcsb.org/structure/1oga"},"stcrdab":{"url":"http://opig.stats.ox.ac.uk/webapps/stcrdab/StrViewer?pdb=1oga"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":{"alpha":{"chains":["D"],"subgroup":"TRAV27"},"beta":{"chains":["E"],"subgroup":"TRBV19"},"mhc_type":"class_i","pdb_code":"1oga"},"title":"HLA-A*02:01 presenting \"GILGFVFTL\" to Alpha/Beta T cell receptor at 1.40Å resolution","unique_chain_count":5}}