{"display":true,"structure":{"allele":{"alpha":{"identifier":"ipd-mhc:CHICKEN08580","locus":"gaga-bf2","match_type":"histo:fuzzy","name":"Gaga-BF2*021:01","slug":"gaga_bf2_021_01","species_stem":"Gaga"},"beta":{}},"assemblies":{"1":{"assembly_name":"1z5l_1","chains":["A","B","E"],"downloaded_at":"2022-11-09T14:31:49.657816"},"2":{"assembly_name":"1z5l_2","chains":["C","D","F"],"downloaded_at":"2022-11-09T14:31:50.719074"}},"assembly_count":null,"assigned_chains":{"beta2m":{"chains":["B","D"],"match_type":"histo:assign_chains","score":1.0,"sequence":"IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM"},"cd1d":{"chains":["A","C"],"match_type":"histo:assign_chains","score":0.97,"sequence":"SEAQQKNYTFRCLQMSSFANRSWSRTDSVVWLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSAGCEMYPGNASESFLHVAFQGKYVVRFWGTSWQTVPGAPSWLDLPIKVLNADQGTSATVQMLLNDTCPLFVRGLLEAGKSDLEKQEKPVAWLSSVPSSAHGHRQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYWHHHHHH"}},"chronology":{"deposition_date":"2005-03-18","deposition_year":2005,"release_date":"2005-07-19","release_year":2005,"revision_date":"2020-07-29","revision_year":2020},"class":"class_i","classical":false,"complex_type":"cd1d","components":["cd1d","beta2m"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"gaga-bf2","manually_edited":{},"missing_residues":[],"page_title":"1Z5L | Non-classical MHC Class I molecule CD1d","pdb_code":"1z5l","pdb_title":"Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1d","peptide":{"actual_sequence":null,"epitope_info":{},"features":[],"full_sequence":null,"gap_info":{},"gapped_sequence":null,"length":{"numeric":null,"text":null},"unnatural_amino_acids":[]},"publication":{"abstract":"Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.","bibjson":{"author":[{"initials":"DM","lastname":"Zajonc","name":"Zajonc DM"},{"initials":"C","lastname":"Cantu","name":"Cantu C"},{"initials":"J","lastname":"Mattner","name":"Mattner J"},{"initials":"D","lastname":"Zhou","name":"Zhou D"},{"initials":"PB","lastname":"Savage","name":"Savage PB"},{"initials":"A","lastname":"Bendelac","name":"Bendelac A"},{"initials":"IA","lastname":"Wilson","name":"Wilson IA"},{"initials":"L","lastname":"Teyton","name":"Teyton L"}],"identifier":[{"id":"10.1038/ni1224","type":"doi"},{"id":"16007091","type":"pubmed"}],"issue":["8"],"journal":{"iso_abbreviation":"Nat. Immunol.","name":""},"pages":["810-8"],"title":"Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.","type":"article","url":"http://www.nature.com/articles/ni1224","volume":["6"],"year":[2005]},"in_pmc":"N","in_pmce":"Y","open_access":"N"},"resolution":"2.20","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/1z5l"},"rcsb":{"url":"https://www.rcsb.org/structure/1z5l"}},"species":{"common_name":"Mouse","match_type":"histo:assign_species","scientific_name":"Mus musculus","slug":"mus_musculus"},"tcr":null,"title":"Non-classical MHC Class I molecule CD1d at 2.20Å resolution","unique_chain_count":2}}