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The unconventional structure is generated by a hydrophobic ridge within the MHC peptide binding groove, found in a set of cattle MHC alleles. Extremely rare in all other species, this feature is seen in a small group of mouse MHC class I molecules. The data generated in this analysis contribute to our understanding of the structural basis for T cell-dependent immune responses, providing insight into what determines a highly immunogenic p-MHC complex, and hence can be of value in prediction of antigenic epitopes and vaccine design.","bibjson":{"author":[{"initials":"IK","lastname":"Macdonald","name":"Macdonald IK"},{"initials":"M","lastname":"Harkiolaki","name":"Harkiolaki M"},{"initials":"L","lastname":"Hunt","name":"Hunt L"},{"initials":"T","lastname":"Connelley","name":"Connelley T"},{"initials":"AV","lastname":"Carroll","name":"Carroll AV"},{"initials":"ND","lastname":"MacHugh","name":"MacHugh ND"},{"initials":"SP","lastname":"Graham","name":"Graham SP"},{"initials":"EY","lastname":"Jones","name":"Jones EY"},{"initials":"WI","lastname":"Morrison","name":"Morrison WI"},{"initials":"DR","lastname":"Flower","name":"Flower DR"},{"initials":"SA","lastname":"Ellis","name":"Ellis SA"}],"identifier":[{"id":"10.1371/journal.ppat.1001149","type":"doi"},{"id":"20976198","type":"pubmed"}],"issue":["10"],"journal":{"iso_abbreviation":"PLoS Pathog.","name":""},"pages":["e1001149"],"title":"MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.","type":"article","url":"https://dx.plos.org/10.1371/journal.ppat.1001149","volume":["6"],"year":[2010]},"in_pmc":"Y","in_pmce":"Y","open_access":"Y"},"resolution":"1.90","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/2xfx"},"rcsb":{"url":"https://www.rcsb.org/structure/2xfx"}},"species":{"common_name":"Domestic cattle","match_type":"histo:assign_species","scientific_name":"Bos taurus","slug":"bos_taurus"},"tcr":null,"title":"BoLA-N*13:01 binding \"VGYPKVKEEML\" at 1.90Å resolution","unique_chain_count":3}}