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Recombinant viruses encoding this engineered determinant primed CTL responses that also reacted to the wildtype epitope with significantly higher functional avidity, and protected against selection of virus mutated at a second CTL determinant and consequent disease progression in persistently infected mice. Collectively, our findings provide a basis for the enhanced immunogenicity of an engineered determinant that will serve as a template for guiding the development of heteroclitic T cell determinants with applications in prevention of CTL escape in chronic viral infections as well as in tumor immunity.","bibjson":{"author":[{"initials":"NS","lastname":"Butler","name":"Butler NS"},{"initials":"A","lastname":"Theodossis","name":"Theodossis A"},{"initials":"AI","lastname":"Webb","name":"Webb AI"},{"initials":"R","lastname":"Nastovska","name":"Nastovska R"},{"initials":"SH","lastname":"Ramarathinam","name":"Ramarathinam SH"},{"initials":"MA","lastname":"Dunstone","name":"Dunstone MA"},{"initials":"J","lastname":"Rossjohn","name":"Rossjohn J"},{"initials":"AW","lastname":"Purcell","name":"Purcell AW"},{"initials":"S","lastname":"Perlman","name":"Perlman S"}],"identifier":[{"id":"10.1371/journal.ppat.1000186","type":"doi"},{"id":"18949029","type":"pubmed"}],"issue":["10"],"journal":{"iso_abbreviation":"PLoS Pathog.","name":""},"pages":["e1000186"],"title":"Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.","type":"article","url":"https://dx.plos.org/10.1371/journal.ppat.1000186","volume":["4"],"year":[2008]},"in_pmc":"Y","in_pmce":"Y","open_access":"Y"},"resolution":"1.80","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/2zsv"},"rcsb":{"url":"https://www.rcsb.org/structure/2zsv"}},"species":{"common_name":"Mouse","match_type":"histo:assign_species","scientific_name":"Mus musculus","slug":"mus_musculus"},"tcr":null,"title":"H2-Kb binding \"RAQIFANI\" at 1.80Å resolution","unique_chain_count":3}}