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Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor alpha (TCRalpha) chain in >87% of these T-cells. Here, the molecular basis for this genetic bias is revealed from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A*0201 (A2-ELA). Unusually, the TRAV12-2 germ line-encoded regions of the TCR dominate the major atomic contacts with the peptide at the TCR/A2-ELA interface. This \"innate\" pattern of antigen recognition probably explains the unique characteristics and extraordinary frequencies of CD8(+) T-cell responses to this epitope.","bibjson":{"author":[{"initials":"DK","lastname":"Cole","name":"Cole DK"},{"initials":"F","lastname":"Yuan","name":"Yuan F"},{"initials":"PJ","lastname":"Rizkallah","name":"Rizkallah PJ"},{"initials":"JJ","lastname":"Miles","name":"Miles JJ"},{"initials":"E","lastname":"Gostick","name":"Gostick E"},{"initials":"DA","lastname":"Price","name":"Price DA"},{"initials":"GF","lastname":"Gao","name":"Gao GF"},{"initials":"BK","lastname":"Jakobsen","name":"Jakobsen BK"},{"initials":"AK","lastname":"Sewell","name":"Sewell AK"}],"identifier":[{"id":"10.1074/jbc.M109.022509","type":"doi"},{"id":"19605354","type":"pubmed"}],"issue":["40"],"journal":{"iso_abbreviation":"J. Biol. 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