{"display":true,"structure":{"allele":{"alpha":{"identifier":"uniprot:P01901","locus":"h2-k","match_type":"histo:exact","name":"H2-Kb","slug":"h2_kb","species_stem":"H2"},"beta":{}},"assemblies":{"1":{"assembly_name":"4mq7_1","chains":["A","B"],"downloaded_at":"2022-11-09T14:45:06.142002"}},"assembly_count":null,"assigned_chains":{"beta2m":{"chains":["B"],"match_type":"histo:assign_chains","score":1.0,"sequence":"IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM"},"cd1d":{"chains":["A"],"match_type":"histo:assign_chains","score":0.73,"sequence":"ADPVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSNDSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGCEVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLLNGTCPQFVSGLLESGKSELKKQEKPVAWLSSVPSSAHGHRQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYWSGR"}},"chronology":{"deposition_date":"2013-09-15","deposition_year":2013,"release_date":"2013-12-18","release_year":2013,"revision_date":"2020-07-29","revision_year":2020},"class":"class_i","classical":false,"complex_type":"cd1d","components":["cd1d","beta2m"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"h2-k","manually_edited":{},"missing_residues":[],"page_title":"4MQ7 | Non-classical MHC Class I molecule CD1d","pdb_code":"4mq7","pdb_title":"Structure of human CD1d-sulfatide","peptide":{"actual_sequence":null,"epitope_info":{},"features":[],"full_sequence":null,"gap_info":{},"gapped_sequence":null,"length":{"numeric":null,"text":null},"unnatural_amino_acids":[]},"publication":{"abstract":"The nature of the antigens recognized by \u03b3\u03b4 T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has remained unclear. Members of the CD1 family of lipid-presenting molecules are suggested ligands for V\u03b41 TCR-expressing \u03b3\u03b4 T cells, the major \u03b3\u03b4 lymphocyte population in epithelial tissues. We crystallized a V\u03b41 TCR in complex with CD1d and the self-lipid sulfatide, revealing the unusual recognition of CD1d by germline V\u03b41 residues spanning all complementarity-determining region (CDR) loops, as well as sulfatide recognition separately encoded by nongermline CDR3\u03b4 residues. Binding and functional analysis showed that CD1d presenting self-lipids, including sulfatide, was widely recognized by gut V\u03b41+ \u03b3\u03b4 T cells. These findings provide structural demonstration of MHC-like recognition of a self-lipid by \u03b3\u03b4 T cells and reveal the prevalence of lipid recognition by innate-like T cell populations.","bibjson":{"author":[{"initials":"AM","lastname":"Luoma","name":"Luoma AM"},{"initials":"CD","lastname":"Castro","name":"Castro CD"},{"initials":"T","lastname":"Mayassi","name":"Mayassi T"},{"initials":"LA","lastname":"Bembinster","name":"Bembinster LA"},{"initials":"L","lastname":"Bai","name":"Bai L"},{"initials":"D","lastname":"Picard","name":"Picard D"},{"initials":"B","lastname":"Anderson","name":"Anderson B"},{"initials":"L","lastname":"Scharf","name":"Scharf L"},{"initials":"JE","lastname":"Kung","name":"Kung JE"},{"initials":"LV","lastname":"Sibener","name":"Sibener LV"},{"initials":"PB","lastname":"Savage","name":"Savage PB"},{"initials":"B","lastname":"Jabri","name":"Jabri B"},{"initials":"A","lastname":"Bendelac","name":"Bendelac A"},{"initials":"EJ","lastname":"Adams","name":"Adams EJ"}],"identifier":[{"id":"10.1016/j.immuni.2013.11.001","type":"doi"},{"id":"24239091","type":"pubmed"}],"issue":[null],"journal":{"iso_abbreviation":"Immunity","name":""},"pages":[null],"title":"Crystal Structure of V\ufffd\ufffd1\ufffd\ufffdT Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human \ufffd\ufffd\ufffd\ufffd T Cells.","type":"article","url":"https://www.sciencedirect.com/science/article/abs/pii/S1074761313004780","volume":[null],"year":[2013]},"in_pmc":"N","in_pmce":"Y","open_access":"N"},"resolution":"2.60","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/4mq7"},"rcsb":{"url":"https://www.rcsb.org/structure/4mq7"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":null,"title":"Non-classical MHC Class I molecule CD1d at 2.60Å resolution","unique_chain_count":2}}