{"display":true,"structure":{"allele":{"alpha":{"identifier":"ipd-imgt:HLA35266","locus":"hla-a","match_type":"histo:exact","name":"HLA-A*02:01","slug":"hla_a_02_01","species_stem":"hla"},"beta":{}},"assemblies":{"1":{"assembly_name":"4uq3_1","chains":["A","B","E"],"downloaded_at":"2022-11-09T14:31:42.019567"},"2":{"assembly_name":"4uq3_2","chains":["C","D","F"],"downloaded_at":"2022-11-09T14:31:42.444760"}},"assembly_count":null,"assigned_chains":{"beta2m":{"chains":["B","D"],"match_type":"histo:assign_chains","score":0.99,"sequence":"MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM"},"class_i_alpha":{"chains":["A","C"],"match_type":"histo:assign_chains","score":1.0,"sequence":"GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE"},"peptide":{"chains":["E","F"],"match_type":"histo:classify_peptide","sequence":"GLSXXL"}},"chronology":{"deposition_date":"2014-06-19","deposition_year":2014,"release_date":"2014-09-17","release_year":2014,"revision_date":"2019-01-16","revision_year":2019},"class":"class_i","classical":true,"complex_type":"class_i_with_peptide","components":["class_i_alpha","beta2m","peptide"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"hla-a","manually_edited":{},"missing_residues":[],"page_title":"4UQ3 | HLA-A*02:01 binding \"GLSXXL\"","pdb_code":"4uq3","pdb_title":"Crystal structure of hla-a0201 in complex with an azobenzene- containing peptide","peptide":{"E":{"actual_length":4,"actual_sequence":"GLSL","chain_id":"E","features":["contains_unnatural","central_gap","short_peptide"],"full_length":6,"full_sequence":"GLSXXL","gap_ends_at":6,"gap_length":2,"gap_sequence":"XX","gap_start_after":3,"gapped_sequence":"GLS--L"},"F":{"actual_length":4,"actual_sequence":"GLSL","chain_id":"F","features":["contains_unnatural","central_gap","short_peptide"],"full_length":6,"full_sequence":"GLSXXL","gap_ends_at":6,"gap_length":2,"gap_sequence":"XX","gap_start_after":3,"gapped_sequence":"GLS--L"}},"peptide_length":6,"peptide_length_name":"hexamer","peptide_neighbours":{"1":{"neighbours":[{"position":59,"residue":"TYR"},{"position":7,"residue":"TYR"},{"position":33,"residue":"PHE"},{"position":167,"residue":"TRP"},{"position":66,"residue":"LYS"},{"position":159,"residue":"TYR"},{"position":63,"residue":"GLU"},{"position":171,"residue":"TYR"},{"position":5,"residue":"MET"}],"position":1,"residue":"GLY"},"2":{"neighbours":[{"position":66,"residue":"LYS"},{"position":167,"residue":"TRP"},{"position":159,"residue":"TYR"},{"position":9,"residue":"PHE"},{"position":7,"residue":"TYR"},{"position":70,"residue":"HIS"},{"position":63,"residue":"GLU"},{"position":45,"residue":"MET"},{"position":67,"residue":"VAL"},{"position":99,"residue":"TYR"}],"position":2,"residue":"LEU"},"3":{"neighbours":[{"position":70,"residue":"HIS"},{"position":99,"residue":"TYR"},{"position":66,"residue":"LYS"},{"position":159,"residue":"TYR"}],"position":3,"residue":"SER"},"6":{"neighbours":[{"position":146,"residue":"LYS"},{"position":124,"residue":"ILE"},{"position":147,"residue":"TRP"},{"position":123,"residue":"TYR"},{"position":80,"residue":"THR"},{"position":81,"residue":"LEU"},{"position":116,"residue":"TYR"},{"position":84,"residue":"TYR"},{"position":95,"residue":"VAL"},{"position":77,"residue":"ASP"},{"position":143,"residue":"THR"}],"position":6,"residue":"LEU"}},"peptide_sequence":"GLSXXL","pockets":{"a":{"a159":{"number":159,"one_letter":"Y","three_letter":"TYR"},"a163":{"number":163,"one_letter":"T","three_letter":"THR"},"a167":{"number":167,"one_letter":"W","three_letter":"TRP"},"a171":{"number":171,"one_letter":"Y","three_letter":"TYR"},"a5":{"number":5,"one_letter":"M","three_letter":"MET"},"a59":{"number":59,"one_letter":"Y","three_letter":"TYR"},"a63":{"number":63,"one_letter":"E","three_letter":"GLU"},"a66":{"number":66,"one_letter":"K","three_letter":"LYS"},"a7":{"number":7,"one_letter":"Y","three_letter":"TYR"}},"b":{"a24":{"number":24,"one_letter":"A","three_letter":"ALA"},"a34":{"number":34,"one_letter":"V","three_letter":"VAL"},"a45":{"number":45,"one_letter":"M","three_letter":"MET"},"a63":{"number":63,"one_letter":"E","three_letter":"GLU"},"a66":{"number":66,"one_letter":"K","three_letter":"LYS"},"a67":{"number":67,"one_letter":"V","three_letter":"VAL"},"a7":{"number":7,"one_letter":"Y","three_letter":"TYR"},"a70":{"number":70,"one_letter":"H","three_letter":"HIS"},"a9":{"number":9,"one_letter":"F","three_letter":"PHE"},"a99":{"number":99,"one_letter":"Y","three_letter":"TYR"}},"c":{"a70":{"number":70,"one_letter":"H","three_letter":"HIS"},"a73":{"number":73,"one_letter":"T","three_letter":"THR"},"a74":{"number":74,"one_letter":"H","three_letter":"HIS"},"a9":{"number":9,"one_letter":"F","three_letter":"PHE"},"a97":{"number":97,"one_letter":"R","three_letter":"ARG"}},"d":{"a114":{"number":114,"one_letter":"H","three_letter":"HIS"},"a155":{"number":155,"one_letter":"Q","three_letter":"GLN"},"a156":{"number":156,"one_letter":"L","three_letter":"LEU"},"a159":{"number":159,"one_letter":"Y","three_letter":"TYR"},"a160":{"number":160,"one_letter":"L","three_letter":"LEU"},"a99":{"number":99,"one_letter":"Y","three_letter":"TYR"}},"e":{"a114":{"number":114,"one_letter":"H","three_letter":"HIS"},"a147":{"number":147,"one_letter":"W","three_letter":"TRP"},"a152":{"number":152,"one_letter":"V","three_letter":"VAL"},"a156":{"number":156,"one_letter":"L","three_letter":"LEU"},"a97":{"number":97,"one_letter":"R","three_letter":"ARG"}},"f":{"a116":{"number":116,"one_letter":"Y","three_letter":"TYR"},"a123":{"number":123,"one_letter":"Y","three_letter":"TYR"},"a143":{"number":143,"one_letter":"T","three_letter":"THR"},"a146":{"number":146,"one_letter":"K","three_letter":"LYS"},"a147":{"number":147,"one_letter":"W","three_letter":"TRP"},"a77":{"number":77,"one_letter":"D","three_letter":"ASP"},"a80":{"number":80,"one_letter":"T","three_letter":"THR"},"a81":{"number":81,"one_letter":"L","three_letter":"LEU"},"a84":{"number":84,"one_letter":"Y","three_letter":"TYR"},"a95":{"number":95,"one_letter":"V","three_letter":"VAL"}}},"publication":{"abstract":"Bioorthogonal cleavable linkers are attractive building blocks for compounds that can be manipulated to study biological and cellular processes. Sodium dithionite sensitive azobenzene-containing (Abc) peptides were applied for the temporary stabilization of recombinant MHC complexes, which can then be employed to generate libraries of MHC tetramers after exchange with a novel epitope. This technology represents an important tool for high-throughput studies of disease-specific T\u2005cell responses.","bibjson":{"author":[{"initials":"JA","lastname":"Choo","name":"Choo JA"},{"initials":"SY","lastname":"Thong","name":"Thong SY"},{"initials":"J","lastname":"Yap","name":"Yap J"},{"initials":"WJ","lastname":"van Esch","name":"van Esch WJ"},{"initials":"M","lastname":"Raida","name":"Raida M"},{"initials":"R","lastname":"Meijers","name":"Meijers R"},{"initials":"J","lastname":"Lescar","name":"Lescar J"},{"initials":"SH","lastname":"Verhelst","name":"Verhelst SH"},{"initials":"GM","lastname":"Grotenbreg","name":"Grotenbreg GM"}],"identifier":[{"id":"10.1002/anie.201406295","type":"doi"},{"id":"25348595","type":"pubmed"}],"issue":["49"],"journal":{"iso_abbreviation":"Angew. Chem. Int. Ed. Engl.","name":""},"pages":["13390-4"],"title":"Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides.","type":"article","url":"https://onlinelibrary.wiley.com/doi/10.1002/anie.201406295","volume":["53"],"year":[2014]},"in_pmc":"N","in_pmce":"N","open_access":"N"},"resolution":"2.10","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/4uq3"},"rcsb":{"url":"https://www.rcsb.org/structure/4uq3"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":null,"title":"HLA-A*02:01 binding \"GLSXXL\" at 2.10&#8491; resolution","unique_chain_count":3}}
