{"display":true,"structure":{"allele":{"alpha":{"identifier":"ipd-imgt:HLA35266","locus":"hla-a","match_type":"histo:exact","name":"HLA-A*02:01","slug":"hla_a_02_01","species_stem":"hla"},"beta":{}},"assemblies":{"1":{"assembly_name":"6mwr_1","chains":["A","B","C","D"],"downloaded_at":"2022-11-09T14:33:18.513646"}},"assembly_count":null,"assigned_chains":{"beta2m":{"chains":["B"],"match_type":"histo:assign_chains","score":1.0,"sequence":"IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM"},"mr1":{"chains":["A"],"match_type":"histo:assign_chains","score":1.0,"sequence":"MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHSGVHMVLQVP"},"tcr_delta":{"chains":["D"],"match_type":"stcrdab","sequence":"AQKVTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKQLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQLEDSAKYFCALGVRAFLRDWGIRVLIFGKGTRVTVEPRSQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSASGLVPR","subgroup":"TRDV1"},"tcr_gamma":{"chains":["C"],"match_type":"stcrdab","sequence":"AGHLEQPQISSTKTLSKTARLECVVSGITISATSVYWYRERPGEVIQFLVSISYDGTVRKESGIPSGKFEVDRIPETSTSTLTIHNVEKQDIATYYCALWDRYYKKLFGSGTTLVVTDKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEESLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNASGLVPR","subgroup":"TRGV9"}},"chronology":{"deposition_date":"2018-10-30","deposition_year":2018,"release_date":"2019-12-18","release_year":2019,"revision_date":"2020-07-29","revision_year":2020},"class":"class_i","classical":false,"complex_type":"mr1_with_gamma_delta_tcr","components":["mr1","beta2m","tcr_delta","tcr_gamma"],"experimental_method":"X-ray diffraction","facets":{},"ligands":[],"locus":"hla-a","manually_edited":{},"missing_residues":[],"page_title":"6MWR | Non-classical MHC Class I molecule MR1 with Gamma/Delta T cell receptor","pdb_code":"6mwr","pdb_title":"Recognition of MHC-like molecule","peptide":{"actual_sequence":null,"epitope_info":{},"features":[],"full_sequence":null,"gap_info":{},"gapped_sequence":null,"length":{"numeric":null,"text":null},"unnatural_amino_acids":[]},"publication":{"abstract":"T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human \u03b3\u03b4 T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a \u03b3\u03b4TCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the \u03b3\u03b4TCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 \u03b13 domain. A similar pattern of reactivity was observed for diverse MR1-restricted \u03b3\u03b4TCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human \u03b3\u03b4 T cells and redefine the parameters for TCR recognition.","bibjson":{"author":[{"initials":"J","lastname":"Le Nours","name":"Le Nours J"},{"initials":"NA","lastname":"Gherardin","name":"Gherardin NA"},{"initials":"SH","lastname":"Ramarathinam","name":"Ramarathinam SH"},{"initials":"W","lastname":"Awad","name":"Awad W"},{"initials":"F","lastname":"Wiede","name":"Wiede F"},{"initials":"BS","lastname":"Gully","name":"Gully BS"},{"initials":"Y","lastname":"Khandokar","name":"Khandokar Y"},{"initials":"T","lastname":"Praveena","name":"Praveena T"},{"initials":"JM","lastname":"Wubben","name":"Wubben JM"},{"initials":"JJ","lastname":"Sandow","name":"Sandow JJ"},{"initials":"AI","lastname":"Webb","name":"Webb AI"},{"initials":"A","lastname":"von Borstel","name":"von Borstel A"},{"initials":"MT","lastname":"Rice","name":"Rice MT"},{"initials":"SJ","lastname":"Redmond","name":"Redmond SJ"},{"initials":"R","lastname":"Seneviratna","name":"Seneviratna R"},{"initials":"ML","lastname":"Sandoval-Romero","name":"Sandoval-Romero ML"},{"initials":"S","lastname":"Li","name":"Li S"},{"initials":"MNT","lastname":"Souter","name":"Souter MNT"},{"initials":"SBG","lastname":"Eckle","name":"Eckle SBG"},{"initials":"AJ","lastname":"Corbett","name":"Corbett AJ"},{"initials":"HH","lastname":"Reid","name":"Reid HH"},{"initials":"L","lastname":"Liu","name":"Liu L"},{"initials":"DP","lastname":"Fairlie","name":"Fairlie DP"},{"initials":"EM","lastname":"Giles","name":"Giles EM"},{"initials":"GP","lastname":"Westall","name":"Westall GP"},{"initials":"RW","lastname":"Tothill","name":"Tothill RW"},{"initials":"MS","lastname":"Davey","name":"Davey MS"},{"initials":"R","lastname":"Berry","name":"Berry R"},{"initials":"T","lastname":"Tiganis","name":"Tiganis T"},{"initials":"J","lastname":"McCluskey","name":"McCluskey J"},{"initials":"DG","lastname":"Pellicci","name":"Pellicci DG"},{"initials":"AW","lastname":"Purcell","name":"Purcell AW"},{"initials":"AP","lastname":"Uldrich","name":"Uldrich AP"},{"initials":"DI","lastname":"Godfrey","name":"Godfrey DI"},{"initials":"J","lastname":"Rossjohn","name":"Rossjohn J"}],"identifier":[{"id":"10.1126/science.aav3900","type":"doi"},{"id":"31857486","type":"pubmed"}],"issue":["6472"],"journal":{"iso_abbreviation":"Science","name":""},"pages":["1522-1527"],"title":"A class of \ufffd\ufffd\ufffd\ufffd T cell receptors recognize the underside of the antigen-presenting molecule MR1.","type":"article","url":"https://www.science.org/doi/10.1126/science.aav3900","volume":["366"],"year":[2019]},"in_pmc":"N","in_pmce":"N","open_access":"N"},"resolution":"3.30","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/6mwr"},"rcsb":{"url":"https://www.rcsb.org/structure/6mwr"},"stcrdab":{"url":"http://opig.stats.ox.ac.uk/webapps/stcrdab/StrViewer?pdb=6mwr"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":{"delta":{"chains":["D"],"subgroup":"TRDV1"},"gamma":{"chains":["C"],"subgroup":"TRGV9"},"pdb_code":"6mwr"},"title":"Non-classical MHC Class I molecule MR1 with Gamma/Delta T cell receptor at 3.30Å resolution","unique_chain_count":4}}