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data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to recognise this new virus; however, we lack data on how T cells are able to recognise this virus. T cells, especially the cytotoxic CD8+ T cells, are critical for viral recognition and clearance. Here we report the X-ray crystallography structure of a T cell receptor, shared among unrelated individuals (public TCR) in complex with a dominant spike-derived CD8+ T cell epitope (YLQ peptide). We show that YLQ activates a polyfunctional CD8+ T cell response in COVID-19 recovered patients. We detail the molecular basis for the shared TCR gene usage observed in HLA-A*02:01+ individuals, providing an understanding of TCR recognition towards a SARS-CoV-2 epitope. Interestingly, the YLQ peptide conformation did not change upon TCR binding, facilitating the high-affinity interaction observed.","bibjson":{"author":[{"initials":"C","lastname":"Szeto","name":"Szeto C"},{"initials":"AT","lastname":"Nguyen","name":"Nguyen AT"},{"initials":"CA","lastname":"Lobos","name":"Lobos CA"},{"initials":"DSM","lastname":"Chatzileontiadou","name":"Chatzileontiadou DSM"},{"initials":"D","lastname":"Jayasinghe","name":"Jayasinghe D"},{"initials":"EJ","lastname":"Grant","name":"Grant EJ"},{"initials":"A","lastname":"Riboldi-Tunnicliffe","name":"Riboldi-Tunnicliffe A"},{"initials":"C","lastname":"Smith","name":"Smith C"},{"initials":"S","lastname":"Gras","name":"Gras S"}],"identifier":[{"id":"10.3390/cells10102646","type":"doi"},{"id":"34685626","type":"pubmed"}],"issue":["10"],"journal":{"iso_abbreviation":"Cells","name":""},"pages":[null],"title":"Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR.","type":"article","url":"https://www.mdpi.com/2073-4409/10/10/2646","volume":["10"],"year":[2021]},"in_pmc":"N","in_pmce":"Y","open_access":"Y"},"resolution":"2.05","same_as":{"pdbe":{"url":"https://www.ebi.ac.uk/pdbe/entry/pdb/7rtd"},"rcsb":{"url":"https://www.rcsb.org/structure/7rtd"}},"species":{"common_name":"Human","match_type":"histo:assign_species","scientific_name":"Homo sapiens","slug":"homo_sapiens"},"tcr":null,"title":"HLA-A*02:01 binding \"YLQPRTFLL\" at 2.05Å resolution","unique_chain_count":3}}